Food allergy, dermatologic diseases, and anaphylaxisInduction of inflammation as a possible mechanism of probiotic effect in atopic eczema–dermatitis syndrome
Section snippets
Subjects
A group of 230 infants suspected of having CMA were recruited between November 1999 and March 2002 to study the effects of probiotics on AEDS symptoms at the Skin and Allergy Hospital of Helsinki University Central Hospital.13 We acquired paired plasma samples of 132 infants (age, 1.4-11.5 months; mean age, 6.5 months; 65% male subjects) for analysis. At the first visit, cow's milk (CM) elimination was started for infants and their breast-feeding mothers. All infants received extensively
Results
After treatment of infants with IgE-associated AEDS, pretreatment-adjusted serum CRP levels were greater in the LGG group than in the placebo group (Table I and Fig 1). However, after treatment, in the whole study population and in infants with IgE-mediated CMA, pretreatment-adjusted serum CRP levels did not differ significantly after probiotic or placebo treatment (Table I).
Among infants with IgE-mediated CMA, adjusted posttreatment serum sE-selectin was higher in the LGG and MIX groups than
Discussion
The data presented document a significant increase in CRP levels in LGG-treated IgE-associated infants with AEDS compared with those seen in the placebo group. CRP is a marker of inflammation, with low levels of CRP reflecting subclinical inflammation, such as in atherosclerosis.15 IL-6 induces gene activation of CRP in hepatocytes and stimulates CRP secretion.16 Here we demonstrated concomitantly increased IL-6 and CRP levels in LGG-treated infants with IgE-associated AEDS. In acute allergic
References (41)
- et al.
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
J Allergy Clin Immunol
(2001) - et al.
Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects
J Allergy Clin Immunol
(2003) - et al.
Probiotics: a novel approach in the management of food allergy
J Allergy Clin Immunol
(1997) - et al.
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Lancet
(2001) - et al.
The failure of oral tolerance induction is functionally coupled to the absence of T cells in Peyer's patches under germfree conditions
Immunobiology
(2001) - et al.
Effect of probiotic Lactobacillus strains in children with atopic dermatitis
J Allergy Clin Immunol
(2003) - et al.
Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy
J Allergy Clin Immunol
(2004) - et al.
Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
Am J Cardiol
(2003) - et al.
Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study
Ann Allergy Asthma Immunol
(2001) Human C-reactive protein: expression, structure, and function
Mol Immunol
(2001)
Displacement of bacterial pathogens from mucus and Caco-2 cell surface by lactobacilli
J Med Microbiol
Mucosal and enterocyte IL-6 production during sepsis and endotoxemia–role of transcription factors and regulation by the stress response
Am J Surg
The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
J Invest Dermatol
Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-beta expression and prevents allergy in adult life
J Allergy Clin Immunol
Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis
J Autoimmun
The intestinal microflora in allergic Estonian and Swedish 2-year-old children
Clin Exp Allergy
Effect of Administration of Lactobacillus casei strain GG on the gastrointestinal microbiata of newborns
Microb Ecol Health Dis
Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption
Appl Environ Microbiol
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
J Immunol
Probiotics in the management of atopic eczema
Clin Exp Allergy
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Supported by Valio Limited, Finland; the Foundation for Nutrition Research, Helsinki, Finland; the Foundation for Paediatric Research, Helsinki, Finland; the Research Foundation of Orion Corporation, Espoo, Finland; and the Kordelin Foundation, Helsinki, Finland.
Disclosure of potential conflict of interest—none disclosed.