Asthma and lower airway diseaseExhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma
Section snippets
Methods
See this article's Methods in the Online Repository at www.jacionline.org for expanded methodology.
Our study population included 107 children with asthma living in Iztapalapa and Nezahualcoyotl, 2 areas of Mexico City with high population and traffic densities, recruited from the allergy clinic of the Hospital Infantil Federico Gómez. The study was conducted as a panel study from January 28 to October 10, 2004. Children were followed for 8 weeks average (minimum, 2, to maximum, 16 weeks) during
Study population
Table I presents the characteristics of the study population. The mean age of participants was 9.5 years. Fifty-six (52.3%) of the children were classified as having mild intermittent, 27.1% mild persistent, and 19.6% moderate persistent asthma. Eighty-nine (89.9%) of the children had positive skin prick test results, with the most common sensitivities to house dust mite (Dermatophagoides pteronyssinus; 62.6%), cat (Fel d 1; 23.2%), and cockroach (Blatella americana; 12.1%). Malondialdehyde was
Discussion
The results of the current study show that malondialdehyde levels in EBC are increased in relation to increased exposure to traffic-related pollutants. In addition, these increased levels of malondialdehyde are associated with lower lung function and increased levels of the inflammatory cytokine IL-8 in nasal lavage. These data suggest that malondialdehyde level in EBC is a suitable biomarker of effect of traffic-related pollutants and could be used as a noninvasive marker in epidemiologic
References (34)
Oxy radicals, lipid peroxidation and DNA damage
Toxicology
(2002)- et al.
Plasma malondialdehyde and erythrocyte glutathione levels in workers with cement dust-exposure
Toxicology
(2005) - et al.
Determination of malondialdehyde in breath condensate by high-performance liquid chromatography with fluorescence detection
J Chromatogr B Analyt Technol Biomed Life Sci
(2002) - et al.
Noninvasive methods for the detection of upper and lower airway inflammation in atopic children
J Allergy Clin Immunol
(2006) - et al.
Oxidative stress-induced DNA damage by particulate air pollution
Mutat Res
(2005) Why and how should we measure oxidative DNA damage in nutritional studies? how far have we come?
Am J Clin Nutr
(2000)- et al.
Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms
Environ Res
(1997) - et al.
Oxidative stress in allergic respiratory diseases
J Allergy Clin Immunol
(2002) Oxidative stress: its role in air pollution and adverse health effects
Occup Environ Med
(2003)- et al.
Serum oxidant and antioxidant levels in diesel exposed toll collectors
J Occup Health
(2004)
Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten
Environ Health Perspect
Exhaled breath condensate in children: pearls and pitfalls
Pediatr Allergy Immunol
Guia de bolsillo para el tratamiento y la prevención del asma
Biostatistical analysis
Regression analysis when the dependent variable is truncated normal
Econometrica
Longitudinal data analysis using generalized linear models
Biometrika
Spirometric function in children of Mexico City compared to Mexican-American children
Pediatr Pulmonol
Cited by (124)
Exhaled breath analysis in disease detection
2021, Clinica Chimica ActaCitation Excerpt :In addition, in patients with asthma, exposure to different allergens may also lead to differences in the eNO levels [217,218]. Moreover, ambient temperature, humidity, air pollution [219,220], and other environmental factors may also influence the exhaled breath composition. Owing to these conditions, breath analysis has limited applications in medical practice.
Successful application of drone-based aeromagnetic surveys to locate legacy oil and gas wells in Cattaraugus county, New York
2021, Journal of Applied GeophysicsAdverse Environmental Exposure and Respiratory Health in Children
2021, Pediatric Clinics of North AmericaA comprehensive survey on investigation techniques of exhaled breath (EB) for diagnosis of diseases in human body
2021, Informatics in Medicine UnlockedEffects of PM <inf>2.5</inf> and NO <inf>2</inf> on the 8-isoprostane and lung function indices of FVC and FEV <inf>1</inf> in students of Ahvaz city, Iran
2019, Saudi Journal of Biological Sciences
Supported by the Mexican Sciences and Technology Council, grant no. 38911-M; the National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga; the Global Allergy and Asthma European Network (GA2LEN) project (European Union contract FOODCT-2004-506378); and the Ministry of Education and Science, Spain, SAB2004-0192.
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.