Food, drug, insect sting allergy, and anaphylaxisEarly exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy
Section snippets
Study population
The research protocol was approved by the Helsinki Review Board of the Assaf Harofeh Medical Center. All newborns (13,234) born from June 10, 2004, to June 30, 2006, at the Assaf-Harofeh Hospital (Zerifin, Israel) were enrolled. Contact details were verified after the routine anticipatory guidance session in which breast-feeding was encouraged but other alternative CMP-based feeding regimens were also discussed. The purpose of the project was explained, and the mothers were asked to fill out a
Study population
Recruitment into the study reached 98.4% (13,019) of our cohort (Fig 1). Initial contact was made by means of telephone interview in 12,473 (95.8%) infants and by means of questionnaire for the remaining 546 (4.2%) infants. The initial information regarding CMP-related adverse effects was obtained within 1 week of the event in most of the cases (58%) and in only 25% of cases in 30 days or longer. In 381 (2.9% of the sample) cases the parents either complained about adverse effects that they
Discussion
This article presents a large, prospective noninterventional study in which several fundamental questions regarding milk allergy were evaluated. To minimize bias, we aimed to reach the highest possible percentage of the target population. We therefore used the least invasive methods for diagnosis, including SPT, rather than measuring specific IgE cow's milk antibodies, and a less demanding open OFC rather than a double-blind placebo-controlled challenge. Importantly, the SPT is considered a
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Cited by (0)
Supported by the Israel Dairy Board.
Disclosure of potential conflict of interest: Y. Katz has received research support from the Israel Dairy Board. The rest of the authors have declared that they have no conflict of interest.
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In partial fulfillment of a PhD thesis at the Sackler School of Medicine, Tel Aviv, Israel.