Food, drug, insect sting allergy, and anaphylaxisUrinary levels of triclosan and parabens are associated with aeroallergen and food sensitization
Section snippets
Study design
Data were obtained from the 2005-2006 NHANES,40 a US-based survey designed to be representative of the noninstitutionalized US population. Participation in the survey is voluntary. A total of 10,348 subjects participated in NHANES 2005-2006. Children aged 6 to 18 years were included in the analyses because childhood is when most sensitization develops. Sociodemographic data, urinary EDC levels, total and specific IgE levels, respiratory disease questionnaire data, and medical condition
Patients' characteristics
Eight hundred sixty subjects had complete data for the primary analysis of urinary EDC levels on aeroallergen sensitization, and 859 had complete data for analysis of EDC levels on food sensitization. Urinary levels of each EDC by tertile or exposure status are shown in Table E1 in this article's Online Repository at www.jacionline.org, and urinary levels according to race/ethnicity are shown in Table E2, Table E3 in this article's Online Repository at www.jacionline.org. Male subjects were
Discussion
In this large, nationally representative sample, we investigated the relationship between EDCs and atopy. We hypothesized that environmental exposure to EDCs would be associated with allergic disease. We were further interested in determining whether the relationship between EDCs and allergic outcomes was dependent on the antimicrobial properties of EDCs. Of the EDCs examined, only urinary levels of triclosan and propyl and butyl parabens were significantly associated with aeroallergen
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Supported by National Institutes of Health grant T32AI007056-31.
Disclosure of potential conflict of interest: E. C. Matsui has consulted for Merck/UBC, has received grants from the NIH, and has received payment for lectures and travel from Indoor Biotechnologies. R. A. Wood has consulted for the Asthma and Allergy Foundation of America, has provided expert witness testimony for the NIH, and has received royalties from UpToDate. C. A. Keet has received grants from the NIH. J. H. Savage declares that she has no relevant conflicts of interest.