Original ArticleFatty acid composition of HDL phospholipids and coronary artery disease
Section snippets
Subjects
Subjects were recruited from a patient population scheduled for diagnostic coronary angiography at Madani Hospital in Tabriz between February 1, 2007 and February 30, 2008. In the present study, 212 patients (151 men and 61 women) were enrolled. Exclusion criteria were age >60 years, a previous hospital admission related to cardiovascular disease, current lipid-lowering medication, and a previous diagnosis of angina, hypercholesterolemia, or diabetes. Hypercholesterolemia was defined as a total
Results
The clinical details and lipid profiles of both groups of patients are presented in Table 1. Patients with angiographically significant coronary atherosclerosis were 3.5 years older than patients without coronary atherosclerosis (P = .003). The mean values of total cholesterol was higher in the patients with SDA than in the patients with MDA (176 ± 41 vs 165 ± 35 mg/dL), reflecting the higher LDL cholesterol in patients with SDA (101 ± 35 vs 92 ± 29 mg/dL).
Palmitic acid was the major fatty acid
Discussion
In this cross-sectional study, we investigated the strength and independence of association between angiographically significant CAD and fatty acid composition of HDL phospholipids. The results showed that higher n-6 and n-3 PUFA percentages of HDL phospholipids are associated with reduced incidence of stenoses >50%. These associations were independent of risk factors found to be correlated with CAD in univariate analysis. These findings are consistent with results from the Nurses’ Health Study
Conclusion
This study shows that PUFA, including linoleic acid, EPA, and DHA content of HDL particles, are inversely associated with the severity of stenoses in coronary arteries. Moreover, EPA and DHA content of HDL particles are inversely associated with the number of lesions producing >50% stenosis in those with significant CAD. These correlations appear to be independent of serum lipoprotein concentrations. Further investigation, while controlling for other risk factors, namely inflammatory markers
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