Clinical ResearchImpact of Bleeding on Mortality After Percutaneous Coronary Intervention: Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials
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REPLACE-2 and ACUITY were sponsored by the Medicines Company, Parsippany, New Jersey. HORIZONS-AMI was sponsored by The Cardiovascular Research Foundation, New York, New York, with grant support from the Medicines Company, Parsippany, New Jersey, and Boston Scientific, Natick, Massachusetts. The sponsors did not provide financial support for this analysis. Drs. Mehran and Dangas report institutional research grant support from Bristol-Myers Squibb/Sanofi-Aventis; and consulting agreements with Abbott Vascular, AstraZeneca, Cardiva, Cordis, The Medicines Company, and Regado Biosciences. Dr. Mehran is also a consultant for Ortho McNeil. Drs. Pocock and Clayton have received grant support and consultant fees from The Medicines Company. Dr. Feit is a shareholder of Eli Lilly, Johnson & Johnson, and The Medicines Company. Dr. White has received research grants from Sanofi-Aventis; Eli Lilly, The Medicines Company, NIH, Pfizer, Roche, Johnson & Johnson, Schering-Plough, Merck Sharpe & Dohme, AstraZeneca, GlaxoSmithKline, Daiichi Sankyo Pharma Development, and Bristol-Myers Squibb; and he has received a consultancy fee from Regado Biosciences. Dr. Bertrand has received consulting fees from Servier Laboratories, Sanofi-Aventis, and Nycomed; and lecture fees from Servier Laboratories and Sanofi-Aventis. Dr. Lansky has received research grants from The Medicines Company, Cordis, Boston Scientific, Medtronic, and Abbott. Dr. Ohman received research grants from Daiichi Sankyo, Eli Lilly and Co., and Maquet; and received consulting fees from Roche, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Liposcience, Merck, Pozen, Inc., Sanofi-Aventis, The Medicines Company, Gilead Sciences, and WebMD. Dr. Lincoff has received research grants from Bristol-Myers Squibb, Kai, Roche, Pfizer, Schering/Merck, and Takeda; and is a consultant for Schering/Merck, Bioline, Bristol-Myers Squibb, Baxter, and Roche. Dr. Stone is consultant to Merck, Eli Lilly, AstraZeneca, The Medicines Company, Abbott Vascular, Boston Scientific, Medtronic, and Bristol-Myers Squibb/Sanofi. All other authors have reported that they have no relationships to disclose.