ReviewPluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers
Section snippets
Pluronic unimers and micelles
Polymer-based nanotechnology became one of the most attractive and fast growing areas of pharmaceutical research. The materials that are currently being researched include polymer micelles, polymer-DNA complexes (“polyplexes”), nanogels, liposomes, and other nanoscale sized materials for medical use that are collectively called nanomedicines. Specific arrangements of polymeric molecules at the nanoscale achieved within such materials represent unique opportunities for safe and efficient
Biological activity of pluronic molecules
The polymers used for drug delivery were considered as biologically inert components that protect drugs from degradation, prolong exposure of drugs to tissues, and enhance transport of drugs into cells. However, this paradigm is undergoing substantial evolution due to growing evidence that select synthetic polymers can drastically alter specific cellular responses [42], [43], [44]. Thus, besides their ability to self-assemble into micelles, Pluronic block copolymers were shown to be potent
Acknowledgments
This study has been supported by a National Institutes of Health grants CA89225, CA116591, NS36229, NS051335 awarded to AVK. We acknowledge the graduate students in the UNMC Pharmaceutical Sciences Graduate Program, Daria Alakhova, Zagit Gaimalov, Gaurav Sahay and Amit Sharma, as well as Dr. Zhihui Yang for their scientific contributions in a number of recent studies in press or in preparation.
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