FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer1
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Key words
Basic fibroblast growth factor
Perlecan
Pericellular matrix
Mechanotransduction
Abbreviations
FGF-2
basic fibroblast growth factor
HS
heparan sulphate
CS
chondroitin sulphate
PG
proteoglycan
GAG
glycosaminoglycan
pERK
phosphorylated extracellularly regulated kinase
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Sources of grant support: Wellcome Trust and Arthritis Research Campaign.
Copyright © 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.