Current best evidence
Clinical research abstract for pediatrician
Alternating ibuprofen and acetaminophen may be more effective in the treatment of fever in children

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Sarrell EM, Wielunsky E, Cohen HA. Antipyretic treatment in young children with fever: Acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. Arch Pediatr Adolesc Med 2006;160:197-202

Question Among young children aged 6 to 36 months with fever, does an alternating regimen of acetaminophen and ibuprofen have an improved antipyretic effect compared with either drug alone?

Design Randomized, double-blind, parallel-group trial.

Setting Three primary pediatric community ambulatory centers in Israel.

Participants 464 children, aged 6 to 36 months, with fever.

Intervention Infants were assigned to receive either acetaminophen (12.5 mg/kg per dose every 6 hours) (n = 154) or ibuprofen

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