Clinical and laboratory observationLeft Ventricular Diastolic Dysfunction in Bronchopulmonary Dysplasia
Section snippets
Case 1
A boy twin B born at 28 weeks’ gestation weighing 829 g was delivered via Caesarian section because of chorioamnionitis. Oligohydramnios complicated the pregnancy. The patient was intubated and treated with surfactant at birth. Because of poor oxygenation with PH, he was treated with high-frequency oscillatory ventilation and inhaled nitric oxide (iNO). He was extubated to nasal continuous positive airway pressure after 5 weeks and discharged home at 4 months receiving oxygen 0.5 L/min. The
Discussion
We report on 2 patients with severe BPD whose clinical course was complicated by LVDD. Both patients had delayed recognition of LVDD. Although there were subtle findings of LVDD by echocardiography, cardiac catheterization was required to make the diagnosis in both patients. Both experienced significant hemodynamic and clinical improvement with afterload reduction therapy.
These findings are interesting because they bring to light a potentially treatable cardiac complication of late BPD.
References (7)
- et al.
Curriculum in cardiology: integrated diagnosis and management of diastolic heart failure
Am Heart J
(2007) - et al.
Normal pulmonary vascular resistance and left ventricular hypertrophy in young infants with bronchopulmonary dysplasia: an echocardiographic and pathologic study
Pediatrics
(1980) - et al.
Cardiac adverse effects of early dexamethasone treatment in preterm infants: a randomized clinical trial
J Clin Pharmacol
(2001)
Cited by (72)
Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care
2024, Clinics in PerinatologyTargeted Neonatal Echocardiography in the Management of Neonatal Pulmonary Hypertension
2024, Clinics in PerinatologyEarly Pulmonary Hypertension in Preterm Infants
2024, Clinics in PerinatologyPathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension: Preclinical Studies
2024, Clinics in PerinatologyBronchopulmonary dysplasia – associated pulmonary hypertension: An updated review
2023, Seminars in PerinatologyPulmonary Vascular Phenotypes of Prematurity: The Path to Precision Medicine
2023, Journal of Pediatrics
Supported by the Thrasher Foundation and grant number 5 K23 RR021021, National Center for Research Resources, a component of the National Institutes of Health.