Original articlePrevalence of Structural Central Nervous System Abnormalities in Early-Onset Type 1 Diabetes Mellitus
Section snippets
Methods
Subjects were drawn from the Western Australian Children's diabetes database, which was established in 1987 at Princess Margaret Hospital. Because this hospital is the only pediatric diabetes referral center in Western Australia, where almost all (99.8%) diagnosed children in the state are registered and treated,29 a representative sample of children with T1DM was potentially available for inclusion. Subjects were considered eligible for the study if they had been diagnosed with T1DM by age 6
Results
Subjects in the no seizure group were well matched with subjects from the combined seizure group on all clinical characteristics, including sex (Table I). The early first seizure subgroup was younger than the rest of the seizure group at diagnosis (2.1 ± 0.9 years vs 3.8 ± 1.4 years; P < .05) and also at the time of the first severe hypoglycemic episode (4.2 ± 1.2 years vs 7.3 ± 1.6 years; P < .05). This was expected, because the division of the experimental group was based on age at the first
Discussion
In this study, we aimed to determine whether documented severe hypoglycemia in subjects with early-onset T1DM is associated with structural abnormalities in the brain as detected by MRI. By using a comparison group of early-onset TIDM children with no history of severe hypoglycemia, we sought to control for other effects related to T1DM per se.
The main findings from this study are the high prevalence of MTS in the total study cohort and the comparable MRI results in those with and those without
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Supported by a Juvenile Diabetes Foundation International grant (1-1999-597).