Original articleIncreased Prevalence of Renal and Urinary Tract Anomalies in Children with Congenital Hypothyroidism
Section snippets
Methods
Prevalence data for congenital hypothyroidism and congenital anomalies was obtained from the New York State Department of Health. The Congenital Malformations Registry of the New York State Department of Health is a repository of case reports on children who are born or reside in New York State and are diagnosed before the age of 2 years with any structural, functional, or biochemical abnormality determined genetically or induced during gestation and not due to birthing events.22
Since there are
Results
There were 980 children with congenital hypothyroidism and 3 661 585 children without congenital hypothyroidism born in New York State from 1992-2005 (Table I). Children with congenital hypothyroidism had a significantly increased risk of congenital anomalies, with all ORs achieving statistical significance with P < .0001 (Table II).
Odds of having congenital renal and urologic anomalies were much higher in children with congenital hypothyroidism with OR of 13.2 (10.6-16.5). OR for
Discussion
Our study shows significantly increased prevalence of specific congenital renal and urologic anomalies in congenital hypothyroidism. Although Cassio et al7 showed increased incidence of internal urogenital system malformations from 0.11% in noncongenital hypothyroidism to 0.43% in subjects with congenital hypothyroidism, these differences did not reach statistical significance, because they had only 1 child with congenital renal and urologic anomalies and the number of subjects with
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The authors declare no potential conflicts of interest, real or perceived.
J.K. is supported by NIH/NIDDK-T32 DK007110-33. F.K. is supported by NIH/NIDDK-T32 DK007110-33; U01 DK63549; U01 DK066174. R.W. is supported by NIH(K12).