Original ArticleEfficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents
Section snippets
Methods
We used a 12-week, randomized controlled study design that compared the impact of the HPLC diet versus a LF diet in producing weight loss in severely obese adolescents. Both groups were informally prescribed an exercise program that included at least 30 minutes of daily moderately vigorous physical activity. Subjects were admitted to the Pediatric Clinical Research Center (CRC) for baseline testing and initiation of the diet, followed at 2-week intervals in the outpatient CRC clinic, and
Results
A total of 51 subjects were consented and randomly assigned for the study. The majority of the subjects were Caucasian (26, 56%); 10 (22 %) were African American; 6 (13%) were Hispanic; and 4 (9%) were Asian. Five subjects (3 HPLC and 2 LF) dropped out before or during the initial in-patient stay; baseline data from these subjects were not included because they did not initiate the intervention. An additional 13 subjects (6 from HPLC, and 7 from LF groups) dropped out during the course of the
Discussion
We report a large, randomized intervention trial in severely obese adolescents, which compared the efficacy and safety of a high protein, low carbohydrate diet versus a low fat hypocaloric diet for weight loss. As has been seen in one other study in adolescents5 and several studies in adults,16, 17, 18, 19, 20 we found a significantly greater short term decrease in BMI-Z and in weight loss with the HPLC diet. This study in adolescents included 6-month follow-up measurements for the 2 dietary
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2019, Contemporary Clinical Trials CommunicationsCitation Excerpt :More recently, low carbohydrate approaches have shown promising weight loss results, including a case series using a slightly more liberalized version of the PSMF diet in inpatient and outpatient settings [15,16]. Despite this promising evidence, the PSMF diet is not a treatment option regularly offered in pediatric tertiary care weight management clinics [14,15,17–20]. The purpose of this paper is to describe the rationale and design of a pilot study to evaluate the acceptability and effectiveness of a revised protein sparing modified fast (rPSMF) implemented as a weight loss treatment option for children and adolescents with severe obesity.
The Effectiveness of Nutrition Specialists on Pediatric Weight Management Outcomes in Multicomponent Pediatric Weight Management Interventions: A Systematic Review and Exploratory Meta-Analysis
2019, Journal of the Academy of Nutrition and DieteticsCitation Excerpt :Multicomponent approaches included modules delivered by nutrition, behavior, physical activity, and medical specialists.39,42,48,51,54-88 Nutrition-focused interventions employed various diet manipulations along with eating behavior modification.89-96 Behavioral interventions included stress management, parent education, stimulus control, guided imagery, therapy aimed at increasing self-efficacy and self-esteem, and nutrition education.97-106
Supported by the Pediatric Clinical Translational Research Center (RR00069), NIH (K24-RR018357-01, T32 DK07658), and the National Cattlemen's Beef Association. The authors declare no conflicts of interest.
No reprints are available from the author.