Original ArticleLongitudinal Assessment of Hemoglobin Oxygen Saturation in Preterm and Term Infants in the First Six Months of Life
Section snippets
Methods
Detailed methods for the CHIME study and for the recording and analysis of Spo2 have previously been reported.2, 3 Written informed consent was obtained for each infant, and the study was approved by the institutional review board at each of the five clinical sites.
The CHIME study included preterm infants born at <1750 g and <35 weeks postmenstrual age (PMA) and healthy term infants. Because of the data processing costs associated with scoring physiological data for this analysis, a priori
Results
The maternal and infant characteristics of the preterm and term infants included in this report are summarized in the Table. To assess the extent that infants included in the analyses differed from those not included, we also compared the included infants with (1) those excluded because of insufficient monitor use and (2) those meeting the monitor use criterion but not selected for inclusion. Consistent with previously published data, infants included in this study had mothers who were older,
Discussion
These data provide insight into expected Spo2 values over time in apparently healthy preterm and term infants during the first 6 months of life studied in the home with noninvasive monitoring. Baseline values were similar for preterm and term infants, with median values of around 98%, although there were changes in median baseline values over time. Acute decreases in Spo2 (intermittent hypoxia) were common in both preterm and term infants and strongly related to PMA. In preterm infants, the
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Cited by (0)
The authors declare no conflicts of interest.
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List of members of the CHIME Study Group is available at www.jpeds.com (Appendix).