ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHD
Section snippets
Discussion
Abnormal brain laterality (ABL) is well established in ADHD. It is also well established that both ADHD (Biederman, 1998, Smalley, 1997) and brain laterality (Geschwind et al., 2002, Thompson et al., 2001) have heritable components. This work investigated whether genes contributing to ABL might also contribute to liability for ADHD reasoning that if this were true, ABL should be more pronounced in families more heavily loaded for ADHD. Increased rightward EEG alpha asymmetry in ADHD was
Role of funding
This work was funded in part by National Institute of Mental Health Grant MH058277 (Smalley), National Institute of Child Health and Human Development Grant HD40275 (Loo), National Institute of Neurological Disease and Stroke NS054124 (Loo), and by National Institute of Mental Health Grant MH082104 (Hale).
Contributors
Author T. Sigi Hale is the first author and had the lead role in all aspects of this research. Author Susan Smalley contributed to study design, analysis methodology, writing and editing the manuscript, interpretation of data, and management and coordination of the research team. Author Jeff Dang was the lead statistician and contributed to all data analyses and writing of statistical results. Authors Grant Hanada and James Macion contributed to EEG collection, processing, analysis, and
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2022, Clinical NeurophysiologyCitation Excerpt :The alpha oscillation cued endogenously was suggested to represent the gate for information in the control of top-down inhibition (Sadaghiani and Kleinschmidt, 2016; Klimesch, 2012), reflecting attentional directionality and excitability (Zhao et al., 2019), or higher-level cognitive functions (e.g., working memory) (Li et al., 2021; Foster et al., 2016; Jensen et al., 2002). Thus, besides poor behavioral performance, dysfunctional alpha modulation as an endophenotype of problems in sustained attention have also been investigated in ADHD studies, where alpha modulation is considered to explain parts of ADHD symptoms and poor behavioral performance (Hale et al., 2015; Hale et al., 2010; Hale et al., 2009a; Hale et al., 2009b). For example, typically developing (TD) children have an “adult-like” pattern of alpha modulation induced by cue (Vollebregt et al., 2015); However, weak alpha lateralization in children with ADHD (Guo et al., 2019; Vollebregt et al., 2016) and short sustained alpha lateralization in adults with ADHD (ter Huurne et al., 2013) indicate dysfunctional sustained attention.
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2020, Clinical NeurophysiologyCitation Excerpt :Central-posterior beta and the theta/beta ratio were also significantly correlated between siblings during the CPT task. Hale et al. (2010a) published a two-study paper investigating familial links in alpha asymmetry in children and adolescents with AD/HD. Participants were split into two groups based on whether their parents showed symptoms of AD/HD.
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2019, Journal of Psychiatric ResearchCitation Excerpt :Further, the largest clinical study to-date found no group difference in frontal alpha asymmetry (Gordon et al., 2010), challenging the view that it serves as a marker of ADHD-related liability. Complicating the picture further, while most studies have focused on frontal regions that can be theoretically understood in the approach/positive-withdrawal/negative framework, some studies have also found differences in posterior alpha asymmetry (Hale et al., 2010, 2009). Several factors may contribute to the mixed picture of frontal alpha asymmetry findings.
Maternal negative affect during infancy is linked to disrupted patterns of diurnal cortisol and alpha asymmetry across contexts during childhood
2016, Journal of Experimental Child Psychology