Elsevier

Leukemia Research

Volume 29, Issue 11, November 2005, Pages 1237-1238
Leukemia Research

Guest editorial
The conflicting roles of the cdk inhibitor p21(CIP1/WAF1) in apoptosis

https://doi.org/10.1016/j.leukres.2005.04.023Get rights and content

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Acknowledgement

NIH Grant CA91146 supports ALG research.

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    The up-regulation of apoptosis related genes (caspase-9, caspase-3, Bax and P53) under hypoxia or Cu2+ exposures indicates that the apoptosis was induced by mitochondrial damage. Besides, P21 plays an important role in the regulation of apoptosis and over expression of P21 enhances the apoptotic response of hepatocytes (Gartel 2005). In the present study, hypoxia and Cu2+ activated the expression of P21, suggesting that p21 was involved in apoptosis.

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    Increased P21 expression has further been reported across a wide variety of tissues in differential gene expression studies using various SMA models (Baumer et al., 2009; Cherry et al., 2017; Corti et al., 2008; Nichterwitz et al., 2020; Olaso et al., 2006; Ruggiu et al., 2012; Tadesse et al., 2008; Wu et al., 2011; Zhang et al., 2008; Zhang et al., 2013). Importantly, p21 can mediate pro-apoptotic or pro-survival signaling through p53-dependent or p53-independent mechanisms that are contingent upon the context of insult and cell type (Gartel, 2005; Gartel and Tyner, 2002). p21 depletion studies have not been undertaken in the context of SMA.

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