Preliminary reportEthnic differences in adiponectin levels☆
Section snippets
Patient characteristics
Twenty-five non-obese women (13 African Americans, 12 Caucasians, body mass index [BMI] < 30) and 60 obese women (24 African Americans, 36 Caucasians, BMI > 30) participated in this study. Written consent was obtained from patients after they were informed of the nature and potential risk of the study. The Institutional Review Board for human subject research approved the protocols used in this study.
Plasma analysis
Blood was collected from patients after a 12-hour fast, and a preservative mixture containing
Results
Table 1 shows that there were no differences in age, BMI, insulin, glucose, and HOMA within either the non-obese or obese groups irrespective of ethnicity. There were no differences in adiponectin levels between the obese African American and Caucasian women. However, plasma adiponectin levels were significantly lower (−72%) in African American compared with the Caucasian non-obese women, despite the lack of difference in insulin concentration and insulin sensitivity (HOMA). Interestingly,
Discussion
Studies have shown that plasma adiponectin levels are negatively associated with the insulin-resistant state irrespective of gender or ethnicity.1, 6, 7, 9, 10 However, there are no studies demonstrating similar associations in African American subjects despite the prevalence of obesity,11 diabetes,12, 13 and insulin resistance14, 15, 16 in this population. In the current study, African Americans and Caucasians with varying degrees of obesity and insulin resistance were examined to determine if
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Supported in part by a grant from the American Diabetes Association (H.A.B.) and National Research Service Award (M.W.H.).