Low-grade inflammation in individuals with the hypertriglyceridemic waist phenotype: Another feature of the atherogenic dysmetabolism
Introduction
The hypertriglyceridemic waist (HTGW) phenotype might be an inexpensive clinical method of identifying elevated coronary artery disease (CAD) risk among asymptomatic individuals as well as patients with glucose intolerance and type 2 diabetes mellitus [1], [2], [3]. The HTGW phenotype is characterized by the presence of an atherogenic metabolic triad of hyperinsulinemia; elevated apolipoprotein B; and small, dense low-density lipoprotein (LDL) [1], [4]. We have presently explored the possibility that the HTGW phenotype is also associated with the presence of low-grade inflammation. The presence of an acute phase response could explain, at least in part, the association between this dysmetabolic and atherogenic metabolism and the risk of developing CAD.
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Study population
In the present study, we analyzed the data collected during the last 5 years in the Tel Aviv Medical Center Inflammation Survey, a registered data bank of the Israeli Ministry of Justice [5], [6], [7], [8], [9], [10], [11]. This is a relatively large survey composed of apparently healthy individuals attending a center for periodic health examinations.
Protocol
In the present study, patients attending the Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, for a routine health examination between
Results
We have presently analyzed the results obtained in 9842 individuals at a mean (SD) age of 44 (11) years. One thousand two hundred forty-nine (12.7%) had the HTGW phenotype, 1164 (11.8%) had the MetS, whereas 8055 (81.8%) individuals had neither the HTGW nor the MetS. We identified 623 individuals with HTGW and no MetS, 538 with the MetS and no HTGW, and 626 with both the MetS and the HTGW phenotype.
In Table 1, we report the different clinical variables of the different groups, whereas the
Discussion
Although previously reported in a relatively small (n = 137) group of women [2], the present study is the first to analyze the presence of low-grade inflammation in both sexes and in a relatively large number of individuals with the HTGW phenotype. Because both low-grade inflammation [18], [19], [20], [21] and the HTGW phenotype [1], [3] predict future cardiovascular events, the presence of the acute phase might be one of the mechanisms that associate the HTGW phenotype with these vascular
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Ori Rogowski and Itzhak Shapira should both be considered first authors.
Competitive interests: None. Ethical approval: Ethical approval was granted to this study. Contribution: All authors contributed to the planning and analysis of the study, the interpretation of the results, as well as the writing of the paper. All the authors have approved the final manuscript.