Molecular Cell
Volume 43, Issue 4, 19 August 2011, Pages 572-585
ArticleHsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy
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Graphical Abstract
Highlights
► Hsp90-Cdc37 interacts with Ulk1, regulating its stability and activation ► Ulk1 phosphorylates Atg13 on S318 and promotes its release to damaged mitochondria ► Ulk1-directed Atg13 S318 phosphorylation is regulated by Hsp90-Cdc37 interactions ► Atg13 S318 phosphorylation is selectively required for mitophagy
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These authors contributed equally to this work
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Present address: Lilly Research Laboratories, Indianapolis, IN 46037, USA
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Present address: Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York, NY 11790, USA
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Present address: Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
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