Molecular Cell
Volume 45, Issue 3, 10 February 2012, Pages 422-432
ArticleExtensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint
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Highlights
► DNA damage-induced sumoylation (DDIS) occurs on a large scale ► DDIS does not depend on the Mec1 checkpoint for activation ► Sumoylation induction exhibits modularity; MRX controls a subset of repair targets ► Defective sumoylation impairs replication and blocks processing of DNA ends.
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Present address: New York University School of Medicine, New York, NY 10016, USA
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Present address: Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA
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