Histamine-induced Ca2+ influx via the PLA2/lipoxygenase/TRPV1 pathway in rat sensory neurons☆
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Acknowledgements
This study was supported by the National Creative Research Initiatives of the Ministry of Science and Technology of Korea.
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2022, Allergology InternationalThe TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators
2021, Biochemical PharmacologyCitation Excerpt :Although the activation of pruriceptive (itch sensitive) sensory neurons is also related to the activation of ion channels partially overlapping with the nociceptor channels, they are typically activated via an indirect way: pruritic ligands bind to their metabotropic receptors thereby activating the pruritic channels via downstream signaling pathways [8,9]. A particular role of the heat-pain mediating TRPV1 and TRPA1 was also described in the transduction of histaminergic and non-histaminergic itch [11,12,33–36]. TRPM3 was recently identified as a heat sensitive TRP channel expressed by somatosensory neurons of the trigeminal and dorsal root ganglia (TGs and DRGs).
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This paper is in honor of Manfred Zimmermann's 70th birthday.