Elsevier

Neuroscience Letters

Volume 381, Issues 1–2, 10–17 June 2005, Pages 131-134
Neuroscience Letters

UCHL1 is associated with Parkinson's disease: A case-unaffected sibling and case-unrelated control study

https://doi.org/10.1016/j.neulet.2005.02.008Get rights and content

Abstract

To avoid the possible confounding effect of population stratification, we employed a discordant sibling study design and a liberalization of the sibling transmission disequilibrium test to confirm the association of the S18Y variant of the ubiquitin carboxi-terminal hydrolase L1 (UCHL1) gene with Parkinson's disease (PD). The study included 497 case–control pairs (427 case-unaffected sibling pairs and 70 case-unrelated control pairs). Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR = 0.18, 95% CI = 0.05–0.64, p = 0.002, recessive model) and in several strata.

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Acknowledgements

This study was supported by the NIH funded studies R01 ES10751 and R01 NS33978 and PO1 NS40256.

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