Elsevier

Neuroscience Letters

Volume 382, Issues 1–2, 1–8 July 2005, Pages 175-178
Neuroscience Letters

The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases

https://doi.org/10.1016/j.neulet.2005.03.008Get rights and content

Abstract

Brain-2 (Brn-2), a Class III POU transcription factor, plays an important role in the development of the neocortex and the establishment of neural cell lineage. Here we performed a yeast two-hybrid screening to identify the Brn-2 binding proteins. We obtained Jun-activation-domain-binding protein 1 (Jab1) as a new Brn-2 binding protein. Direct interaction between Brn-2 and Jab1 was confirmed by using a surface plasmon resonance biosensor. Considering the involvement of Jab1 in the onset of the neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, the interaction between Brn-2 and Jab1 may provide some insights into the understanding of neuronal development and neurodegenerative diseases.

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Acknowledgement

This study was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan.

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    Present address: Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama 351-0198, Japan.

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