Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor
Section snippets
Acknowledgments
This work was supported by the IBST Grant 2005 from Inje University (W.S.) and NIH grant MH48866 (K.-S.K.). We would like to thank Drs Heller, Palvimo and Mouradian for material, and members of IBST for their critical discussions and suggestions, especially to Drs. I. Ha, W. Song, S.-H. Chung, and J.-S Han.
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2016, Journal of Biological ChemistryEarly-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion
2015, International Journal of Developmental NeuroscienceCitation Excerpt :Simultaneously, we detected age-dependent (developmental) increases in the number of TH-IR neurons in control and MS rats, particularly in males (Chocyk et al., 2011b). Considering that (1) all dopaminergic neurons are generated prenatally (Zecevic and Verney, 1995; Orme et al., 2009), (2) postnatal neurogenesis in the midbrain remains controversial (Frielingsdorf et al., 2004; Shan et al., 2006; Zhao and Janson Lang, 2009), and (3) gonadal hormones (testosterone and estradiol) are known to affect the enzymatic and transcriptional activity of TH (Kumai et al., 1995; Jeong et al., 2006; Sabban et al., 2010; Maharjan et al., 2010), our study and the studies of others have revealed the effects of ELS, age and sex on TH expression (as protein) in particular neurons but not on the number of dopaminergic neurons per se. Therefore, TH immunodetection has a serious limitation when applied to the examination of developmental changes in the entire population of dopaminergic neurons.
Behavioral characterization of non-copulating male mice
2013, Hormones and BehaviorCitation Excerpt :Hormones can modulate sexual behavior by modifying the dopaminergic system (Mani and Portillo, 2010; Zheng, 2009). Testosterone and estradiol increase the activity of the rate-limiting enzyme of dopamine biosynthesis, tyrosine hydroxylase (TH) (Jeong et al., 2006; Pasqualini et al., 1995). Estradiol also regulates dopamine release and reuptake (Becker, 1990; Thompson and Moss, 1994).
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
2012, Free Radical Biology and MedicineCitation Excerpt :For example, previous studies showed that during oxidative stress, DJ-1 may modulate the expression of genes such as glutamate–cysteine ligase, the rate-limiting enzyme of glutathione biosynthesis; extracellular superoxide dismutase (SOD3) [16,17]; or manganese superoxide dismutase (MnSOD) synergistic with peroxisome proliferator-activated receptor γ coactivator 1α [18]. DJ-1 can also modulate expression of several other genes including androgen receptor reporter activity by interacting with PIASx, which is known as androgen receptor-interacting protein-3 [19,20], as well as tyrosine hydroxylase [21] and Bax [22]. DJ-1 is mainly localized in the cytosol and is also found in mitochondria and the nucleus [23,24].
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These authors contributed equally to this work.