ReviewStem cell-based cell replacement strategies for the central nervous system
References (49)
- et al.
Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord
Experimental Neurology
(2001) - et al.
Embryonic stem cells express neuronal properties in vitro
Developmental Biology
(1995) - et al.
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Cell
(1999) - et al.
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
Neuron
(1996) - et al.
Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury
Transplant Immunology
(2005) - et al.
Activin exerts a neurotrophic effect on cultured hippocampal neurons
Brain Research
(1997) - et al.
Human oligodendrocytes derived from embryonic stem cells: effect of noggin on phenotypic differentiation in vitro and on myelination in vivo
Molecular and Cellular Neurosciences
(2007) - et al.
Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells
Journal of Neuroimmunology
(2007) - et al.
Therapeutic applications of oligodendrocyte precursors derived from human embryonic stem cells
Current Opinion in Biotechnology
(2007) - et al.
Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease
Experimental Neurology
(1997)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Cell
Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury
Journal of Neurosurgery
Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis
Glia
Neural stem cells in the adult nervous system
Journal of Hematotherapy & Stem Cell Research
Embryonic stem cell-derived glial precursors: a source of myelinating transplants
Science (New York, NY)
Growth factors regulate the survival and fate of cells derived from human neurospheres
Nature Biotechnology
Complement targeting of nonhuman sialic acid does not mediate cell death of human embryonic stem cells
Nature Medicine
Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm
Regenerative Medicine
The role of oligodendrocytes and myelin on axon maturation in the developing rat retinofugal pathway
Journal of Neuroscience
Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells
Stem Cells (Dayton, Ohio)
Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year
Archives of Neurology
Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease
Annals of Neurology
Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
Proceedings of the National Academy of Sciences of the United States of America
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
Journal of Neuroscience
Cited by (44)
Neural regeneration therapies for Alzheimer's and Parkinson's disease-related disorders
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseMesenchymal stem cell therapies in brain disease
2019, Seminars in Cell and Developmental BiologyCitation Excerpt :Whether these MSCs are fully cleared from the body or are so widely diffused that they cannot be tracked is unclear; regardless, this would limit the number of MSCs that could have the potential to reach the brain. As an alternative, localized injection of MSCs has been employed, such as intranasal application as a non-invasive method to deliver SC directly into the central nervous system (CNS) [43]. These localized delivery methods, such as intranasal delivery, appear to minimize the issue of lung entrapment and yield higher homing of injected MSCs to the brain [101,102].
Transplantation of Human Umbilical Cord Blood Mononuclear Cells Attenuated Ischemic Injury in MCAO Rats via Inhibition of NF-κB and NLRP3 Inflammasome
2018, NeuroscienceCitation Excerpt :Correspondingly, as shown in Fig. 6(B, C and D), the contents of VEGF, Ang-1 and Tie-2 were elevated in cbMNCs-treated group, indicating the more potent angiogenesis of cbMNCs. Transplantation of stem cells may be considered as an alternative treatment for the neurodegenerative diseases (Pluchino et al., 2005; Sharp and Keirstead, 2009; Erceg et al., 2010; Bigini et al., 2011; Reimers et al., 2012). One of the advantages of the cbMNCs is that the cells can prevent the graft-versus-host disease (Parmar et al., 2014).
Mesenchymal stem cells as therapeutic agents and potential targeted gene delivery vehicle for brain diseases
2012, Journal of Controlled ReleaseCitation Excerpt :Besides the neurotrophic factors, MSCs can produce the extracellular matrix molecules that can support neural cell attachment, growth and axonal extension [19]. Several studies have proved that MSCs can be induced to express neural markers in vitro [20,21], while after stem cells migrating in the brain, some new neurons in the adult human hippocampus have been found [18,22,23]. There is no precise definition of mechanisms of stem cell‐based therapy for brain diseases yet; however, as beneficial effects have been demonstrated, details inside cell therapy need further investigation.