Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment
Section snippets
Acknowledgments
This research was partly supported by National Basic Research Program of China (973 Program) (No. 2007CB512308), National Hi-Tech Research and Development Program of China (863 Program) (No. 2007AA0200Z435), National Natural Science Foundation of China (Nos. 30770779; 30825014), and the Scientific Research of Foundation of Graduate of School of Southeast University (YBJJ0824).
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White matter microstructural abnormalities in amnestic mild cognitive impairment: A meta-analysis of whole-brain and ROI-based studies
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Abnormal functional connectivity of the default mode network in remitted late-onset depression
2013, Journal of Affective DisordersCitation Excerpt :Preliminary studies on the relationship between the influences of two behaviours on a large-scale neural network level have been performed. Our group has found that both remitted geriatric depression patients and aMCI patients had global, abnormal topology of their white matter structure (Bai et al., 2012, 2009b, 2009c; Yuan et al., 2007), which is the basis of the functional connectivity (FC) network. Accompanying the structural network abnormalities, abnormal subregions in the amygdala-based functional connectivity network of aMCI patients with depression overlapped with areas of the memory network (Xie et al., 2012) further it was confirmed by the hippocampal FC network (Goveas et al., 2011).
Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype
2013, Alzheimer's and DementiaCitation Excerpt :In addition to quantitative network alterations, functionally relevant microstructural changes are seen in white matter in presymptomatic carriers of mutations for familial AD, nondemented elderly individuals and subjects with MCI [184–186]. White matter degeneration seems independent of hippocampal atrophy in amnestic MCI [187], and somewhat independent of gray matter degeneration in AD [188,189]. White matter changes independent of regional cortical degeneration are suggested as a consequence of unique myelin-related pathology [190].
White matter integrity and reaction time intraindividual variability in healthy aging and early-stage Alzheimer disease
2012, NeuropsychologiaCitation Excerpt :Recently, Bartzokis (2009) has suggested that AD may begin with compromised myelin. This is supported by evidence demonstrating strong links between hippocampal atrophy, an early region of decline in AD, and atrophy of critical white matter regions (Villain et al., 2010; but see Bai et al., 2009). Furthermore, frontal, temporal, corpus callosal, and parietal white matter integrity have been associated with memory and executive function in AD (Amar, Bucks, Lewis, Scott, & Wilcock, 1996; Anstey et al., 2007; Huang & Auchus, 2007; Kavcic et al., 2008).