Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models
Research highlights
▶ Micro-RNA 146a (miRNA-146a) is a mouse and human brain-enriched miRNA implicated in the innate immune response and inflammatory signaling. ▶ miRNA-146a was found to be up-regulated both in Alzheimer disease brain and in several transgenic mouse models of Alzheimer's disease including Tg2576, TgCRND8, PSAPP, 3xTg-AD and 5xFAD. ▶ In IL-1β stressed primary co-cultures of human neuronal and glial (HNG) cells, miRNA-146a up-regulation was quenched using the NF-кB inhibitors curcumin, PDTC or CAY10512, suggesting a novel regulatory interplay between the inducible, pro-inflammatory transcription factor NF-кB and miRNA-146a.
Section snippets
Acknowledgments
Thanks are extended to Darlene Guillot and Aileen Pogue for expert technical assistance, and to Drs. C. Bergeron, C. Chen, J. Deck, P.E. Fraser, E. Head, D.R. McLachlan, W. Poon, G. Tejada and T. Saing for Tg-AD mouse and human brain and retinal tissues or extracts. Some of the brain tissues used in this project was provided by the Institute for Memory Impairments and Neurological Disorders and the University of California at Irvine Alzheimer's Disease Research Center (UCI-ADRC); funding for
References (30)
- et al.
Probing the biology of Alzheimer's disease in mice
Neuron
(2010) - et al.
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
J. Biol. Chem.
(2001) - et al.
Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment
Brain Res.
(2002) - et al.
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls
Am. J. Pathol.
(2005) - et al.
Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells
J. Inorg. Biochem.
(2007) - et al.
An NF-кB-sensitive miRNA-146a-mediated inflammatory circuit in AD and in stressed human brain cells
J. Biol. Chem.
(2008) - et al.
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction
Neuron
(2003) - et al.
Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation
Neurosci. Lett.
(2010) MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases
Brain Res.
(2010)- et al.
Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex
Neurosci. Lett.
(2009)