Increased neural response to trauma scripts in posttraumatic stress disorder following paroxetine treatment: A pilot study
Research highlights
► Paroxetine, but not placebo, treatment is associated with increased OFC activation. ► Paroxetine and placebo treatments are both associated with increased activation in the ACC. ► SSRI treatment may act more specifically on orbitofrontal circuits that modulate fear extinction. ► These pilot data reveal putative mechanisms for SSRI treatment in PTSD. ► Our findings substantiate the need for further imaging studies of SSRI treatment in PTSD.
Section snippets
Acknowledgments
This study was supported by an Investigator Initiated Research Grant from GlaxoSmithKline and NIH research grants to JDB R01 HL088726, K24 MH076955, T32 MH067547-01, R01 MH56120, and the clinical interactions network (CIN) of the Atlanta Clinical and Translational Sciences Institute (ACTSI). We wish to acknowledge Sinead Quinn, Delicia Votaw, C.N.M.T. and Margie Jones, C.N.M.T., for their assistance with imaging and analysis procedures.
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