Group II metabotropic glutamate receptors in the striatum of non-human primates: Dysregulation following chronic cocaine self-administration
Highlights
► Group II metabotropic glutamate (mGluRs) are involved in the effects of cocaine. ► We studied the density of group II mGluRs following chronic cocaine in monkeys. ► We found higher levels of binding in the dorsal striatum, not the ventral striatum. ► Therefore the dorsal striatum may be more sensitive to the effects of cocaine. ► Treatments for cocaine that target these receptors may be efficacious.
Section snippets
Acknowledgement
This work was supported by NIDA DA26590 (TJRB), DA09085 (LJP) and DA06634 (P50).
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