Elsevier

Neurobiology of Aging

Volume 29, Issue 8, August 2008, Pages 1137-1139
Neurobiology of Aging

Open peer commentary
Clinicopathologic correlates in the oldest-old: Commentary on “No disease in the brain of a 115-year-old woman”

https://doi.org/10.1016/j.neurobiolaging.2008.04.015Get rights and content

Abstract

den Dunnen et al. [den Dunnen, W.F.A., Brouwer, W.H., Bijlard, E., Kamphuis, J., van Linschoten, K., Eggens-Meijer, E., Holstege, G., 2008. No disease in the brain of a 115-year-old woman. Neurobiol. Aging] had the opportunity to follow up the cognitive functioning of one of the world's oldest woman during the last 3 years of her life. They performed two neuropsychological evaluations at age 112 and 115 that revealed a striking preservation of immediate recall abilities and orientation. In contrast, working memory, retrieval from semantic memory and mental arithmetic performances declined after age 112. Overall, only a one-point decrease of MMSE score occurred (from 27 to 26) reflecting the remarkable preservation of cognitive abilities. The neuropathological assessment showed few neurofibrillary tangles (NFT) in the hippocampal formation compatible with Braak staging II, absence of amyloid deposits and other types of neurodegenerative lesions as well as preservation of neuron numbers in locus coeruleus. This finding was related to a striking paucity of Alzheimer disease (AD)-related lesions in the hippocampal formation. The present report parallels the early descriptions of rare “supernormal” centenarians supporting the dissociation between brain aging and AD processes. In conjunction with recent stereological analyses in cases aged from 90 to 102 years, it also points to the marked resistance of the hippocampal formation to the degenerative process in this age group and possible dissociation between the occurrence of slight cognitive deficits and development of AD-related pathologic changes in neocortical areas. This work is discussed in the context of current efforts to identify the biological and genetic parameters of human longevity.

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Conflicts of interest

No competing interest or conflict of interest.

Acknowledgement

Supported by NIH grants AG02219 and AG05138.

References (32)

  • B.A. Blansjaar et al.

    Prevalence of dementia in centenarians

    Int. J. Geriatr. Psychiatry

    (2000)
  • M. Dello Buono et al.

    Quality of life and longevity: a study of centenarians

    Age Ageing

    (1998)
  • den Dunnen, W.F.A., Brouwer, W.H., Bijlard, E., Kamphuis, J., Holstege, G., in press. No disease in the brain of a...
  • M.M. Fichter et al.

    Dementia and cognitive impairment in the oldest old in the community: prevalence and comorbidity

    Br. J. Psychiatry

    (1995)
  • B.J. Geesaman et al.

    Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

    Proc. Natl. Acad. Sci. U.S.A.

    (2003)
  • P. Giannakopoulos et al.

    Dementia in the oldest-old: quantitative analysis of 12 cases from a psychiatric hospital

    Dementia

    (1994)
  • Cited by (0)

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