Elsevier

Neurobiology of Aging

Volume 33, Issue 1, January 2012, Pages 209.e3-209.e8
Neurobiology of Aging

Genetic reports abstract
The chromosome 9 ALS and FTD locus is probably derived from a single founder

https://doi.org/10.1016/j.neurobiolaging.2011.08.005Get rights and content
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Abstract

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.

Keywords

Genetics
Amyotrophic lateral sclerosis
Frontotemporal dementia
Finland

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