Neuron
Volume 77, Issue 3, 6 February 2013, Pages 406-424
Journal home page for Neuron

Review
Probing and Regulating Dysfunctional Circuits Using Deep Brain Stimulation

https://doi.org/10.1016/j.neuron.2013.01.020Get rights and content
Under an Elsevier user license
open archive

Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily disorders of circuit function, or “circuitopathies.” These developments have been accompanied by advances in neurosurgical techniques with the increasingly widespread utilization of deep brain stimulation (DBS) to recalibrate dysfunctional circuits. The versatility of DBS as both a probe and modulator of neural circuits is making it a powerful tool to study the human brain, helping provide important details of the pathophysiology of circuit dysfunction. We are currently in a phase of active investigation to determine which circuits and disorders could be treated with DBS. Here we review recent advances in the DBS field and discuss potential future directions in targeted intracranial neuromodulation.

Cited by (0)