Systems neuroscienceResponse preparation and inhibition: The role of the cortical sensorimotor beta rhythm
Section snippets
Paradigm and data acquisition
Two macaque monkeys (GE and LU) were trained to discriminate visual stimuli at the Laboratory of Neuropsychology, National Institute of Mental Health (NIMH) (Bressler et al 1993, Ledberg et al 2007). Animal care was in accordance with NIMH guidelines at the time. All efforts were made to minimize the number of animals used and their suffering. Each stimulus consisted of four solid squares arranged as (1) right-slanted line, (2) left-slanted line, (3) right-slanted diamond, or (4) left-slanted
Time-frequency analysis
Power spectra were computed and averaged across recording sites in each monkey for each of the sliding analysis windows over the entire trial time period. Coherence and Granger causality spectra were computed for all pairwise combinations of sites and then averaged in each monkey for each window. Fig. 2 shows the result for GE (a) and LU (b) (left column: power; center column: coherence; and right column: Granger causality) where the top row is the GO condition, the middle row is the NO-GO
Discussion
Time-frequency analysis was carried out on LFPs from the sensorimotor cortex of two macaque monkeys performing a visuomotor GO/NO-GO task. Beta desynchronization was observed for both GO and NO-GO conditions shortly after stimulus onset. Following the GO/NO-GO decision, significant beta rebound occurred in the NO-GO condition, but not in the GO condition within the time interval of recording [−90 ms, 505 ms]. These events can be better understood by examining their latency of occurrence in
Conclusion
In sum, power, coherence and Granger causality in the beta frequency range as functions of time were shown to yield information that complements the traditional ERP studies. While these functions may not directly shed light on the neural mechanisms of response preparation and inhibition, they could nevertheless reliably indicate, via beta desynchronization and rebound, the onset and the completion of these two events, respectively. When contrasted between GO and NO-GO conditions, these timing
Acknowledgments
This work was supported by National Institute of Mental Health grants MH064204, MH071620, and MH070498. We thank the referees for insightful comments.
References (46)
- et al.
Electrophysiological correlates for response inhibition in a go/nogo task
Clin Neurophysiol
(2001) - et al.
Frequency decomposition of conditional Granger causality and application to multivariate neural field potential data
J Neurosci Methods
(2006) Effects of attention and stimulus probability on ERPs in a go/nogo task
Biol Psychol
(1993)- et al.
ERP components in go/nogo tasks and their relation to inhibition
Acta Psychol (Amst)
(1999) - et al.
Mechanisms of human attention: event-related potentials and oscillations
Neurosci Biobehav Rev
(2001) - et al.
On the human sensorimotor-cortex beta rhythm: sources and modeling
Neuroimage
(2005) - et al.
Relation of a negative ERP component to response-inhibition in a go/no-go task
Electroencephalogr Clin Neurophysiol
(1992) - et al.
Task-dependent modulations of cortical oscillatory activity in human subjects during a bimanual precision grip task
Neuroimage
(2003) - et al.
Field potential oscillatory bursts in parietal cortex before and during reach
Brain Res
(1995) - et al.
ERPs to response production and inhibition
Electroencephalogr Clin Neurophysiol
(1985)
Event-related EEG/MEG synchronization and desynchronization: basic principles
Clin Neurophysiol
Motor imagery activates primary sensorimotor area in humans
Neurosci Lett
Foot and hand area mu rhythms
Int J Psychophysiol
On the existence of different types of central beta rhythms below 30 Hz
Electroencephalogr Clin Neurophysiol
Post-movement beta synchronizationA correlate of an idling motor area?
Electroencephalogr Clin Neurophysiol
P300 as a clinical assay: rationale, evaluation, and findings
Int J Psychophysiol
EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humans
Neurosci Lett
Synchronous cortical oscillatory activity during motor action
Curr Opin Neurobiol
Functional segregation of movement-related rhythmic activity in the human brain
Neuroimage
No-go activity in the frontal association cortex of human subjects
Neurosci Res
Suppression of visually initiated hand movement by stimulation of the prefrontal cortex in the monkey
Brain Res
The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study
Neuroimage
New look at statistical-model identification
IEEE Trans Automat Contr Ac
Cited by (231)
Diverse beta burst waveform motifs characterize movement-related cortical dynamics
2023, Progress in NeurobiologyChanging connectivity between premotor and motor cortex changes inter-areal communication in the human brain
2023, Progress in NeurobiologyEmerging biometric methodologies for human behaviour measurement in applied sensory and consumer science
2023, Digital Sensory Science: Applications in New Product Development