Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment
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Highlights
► Commonly carried MTHFR gene polymorphism affects plasma homocysteine levels. ► It also accelerates brain tissue loss in the elderly with mild cognitive impairment. ► We have mapped MTHFR brain structure associations in 3D in two independent cohorts. ► We suggest a causal pathway for homocysteine-mediated brain atrophy in the elderly.
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Investigators within ADNI contributed to the design and implementation of ADNI and/or provided data but not participate in analysis or writing of this report. For a complete listing of ADNI investigators, see http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
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A full list of principal CHS investigators and institutions may be found at http://www.chs-nhlbi.org/pi.htm.
Copyright © 2012 The Authors. Published by Elsevier Inc.