ReviewCoffee and type 2 diabetes: From beans to beta-cells
Introduction
The importance of primary prevention of type 2 diabetes is increasingly recognized, and this has stimulated an interest in the role of dietary factors in the etiology of type 2 diabetes. Until recently, research on dietary factors and risk of type 2 diabetes has mostly focused on macronutrients [1]. However, micronutrients and phytochemicals may also affect glucose metabolism [2]. In 2002, results from a Dutch cohort study on coffee consumption and risk of type 2 diabetes were reported. Participants who consumed 7 or more cups of coffee per day were 0.50 (95% confidence interval [CI] 0.35–0.72) times as likely to develop type 2 diabetes as compared with those who consumed 2 or fewer cups per day [3]. This finding was followed by the rapid publication of the results of more than 15 epidemiological studies on habitual coffee consumption in relation to insulin sensitivity, hyperglycemia and risk of type 2 diabetes in various countries [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]. In this review, I will briefly discuss the strength of the evidence for a relation between higher coffee consumption and a lower risk of type 2 diabetes. Furthermore, I will describe suggested mechanisms for effects of coffee components on glucose metabolism, give suggestions for further research, and discuss possible implications for public health.
Section snippets
Coffee consumption and risk of type 2 diabetes
Studies on coffee consumption and risk of type 2 diabetes have been reviewed systemically [20]. Nine cohort studies on coffee consumption and risk of type 2 diabetes included a total of 193,437 participants and 8394 incident cases of type 2 diabetes. The summary multivariate-adjusted relative risk (RR) of type 2 diabetes was 0.65 (95% CI 0.54–0.78) for the highest (≥6 or ≥7 cups per day) and 0.72 (95% CI 0.62–0.83) for the second highest (4–6 cups per day) category of coffee consumption
Mechanisms
Table 2 shows a selection of coffee components [24], [25], [26] and suggested mechanisms for effects of these components on glucose metabolism [27], [28], [29], [30], [31], [32], [33], [34], [35]. Most data on effects of coffee components on glucose metabolism are based on animal and in vitro studies, and the relevance for the development of type 2 diabetes in humans is currently unclear. However, the results suggest that an effect of coffee consumption on glucose metabolism is biologically
Suggestions for further research
Two types of studies seem to be priorities for further research in the area of coffee consumption and glucose metabolism. First, a longer-term randomized trial of coffee consumption with appropriate outcome measures is warranted. The inverse associations between decaffeinated coffee and risk of type 2 diabetes in cohort studies suggest that the inclusion of an intervention with decaffeinated coffee would be worthwhile. Outcome measures should not be solely based on measurements in fasting blood
Relevance for public health
Increased physical activity and weight management should be the mainstay of public health strategies to prevent type 2 diabetes. The beneficial effects of physical activity and weight management are not limited to type 2 diabetes, but can also lower the risk of cardiovascular diseases, various types of cancer, and premature mortality [66], [67], [68], [69].
For choices of individuals regarding coffee consumption the potential effect of coffee consumption on risk of type 2 diabetes can be taken
Acknowledgement
R.M.v.D. is partly supported by the Netherlands Organization for Scientific Research (ZonMw VENI grant No. 916.46.077).
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2018, Journal of the American College of CardiologyCitation Excerpt :The NHS showed no association between coffee and hypertension development (54). Polyphenolic antioxidants in coffee tend to improve glucose metabolism and insulin sensitivity (55). Several large epidemiological studies have reported a dose-dependent relationship between consumption of coffee (both caffeinated and decaffeinated) and reduced risk of type 2 DM (56,57).