Original articleDemographic and Geographic Features of Exfoliation Glaucoma in 2 United States-Based Prospective Cohorts
Section snippets
Description of the Cohort at Risk for Exfoliation Glaucoma
The NHS is an ongoing population-based cohort of registered female nurses. The NHS was established in 1976 when 121 700 United States women were invited to complete a questionnaire regarding lifestyle, health behavior, and chronic diseases. The HPFS is an ongoing cohort created in 1986 when 51 529 male health professionals (dentists, veterinarians, pharmacists, optometrists, osteopaths, and podiatrists) completed a similar health survey. The participants in both cohorts have been followed up
Results
Two hundred eighty-eight incident EG or EGS cases were identified in the NHS and 60 incident EG or EGS cases were identified in the HPFS during the study period. The total accrued person-time was 1 761 676 person-years (1 289 264 in the NHS and 472 412 in the HPFS). Of the 78 955 women and 41 191 men who ever contributed person-time, 5482 (7.0%) women and 4591 (11.2%) men reported Scandinavian ancestry, 12 967 (16.4%) women and 9484 (23.0%) men reported Southern European ancestry, 58 662
Discussion
This large, prospective study of more than 20 years in 2 United States-based cohorts confirmed established associations with age and family history and EG or EGS, as well as provided new data on associations with gender, eye color, and ancestry. Importantly, those with a lifetime residential history of living in the middle tier and the southern tier of the United States was associated with 47% and 75% reduced risk, respectively, compared with living in the northern tier, and across the life
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
A Physician Scientist Award from Research to Prevent Blindness, Inc., New York, New York, supports Dr. Pasquale. The National Institutes of Health, Bethesda, Maryland (grant nos.: CA87969, CA55075, EY09611, HL35464, EY019511, EY015473 [LRP]); the Arthur Ashley Williams Foundation, Holliston, Massachusetts; and the Harvard Glaucoma Center of Excellence (JLW and LRP), Boston, Massachusetts.