CASE REPORTHyalinizing clear cell carcinoma of salivary gland: an aggressive variant
Section snippets
Case report
In December 2000, a 57 year-old female presented to the Ear Nose and Throat Department in St. James's Hospital, Dublin, Ireland, with a 4-month history of severe pain in her right ear and throat along with profound anaesthesia of the right side of her tongue. Coinciding with this history of pain, the patient had a rash affecting her ear and neck on that side, diagnosed as shingles. On examination, there was a large ulcerated mass at the base of her tongue with a palpable cervical lymph node on
Pathology
The excision contained a large tumour mass (3.5 cm in maximum diameter) occupying the body and posterior tongue. While an ulcerated elevated nodule was present, sectioning revealed that the bulk of tumour was submucosal. The cut surface of the tumour was firm and white with a whorled appearance. It extended to the deep margins of the resection and there was extensive nodal involvement by tumour with a total of seven positive nodes retrieved from levels I, II, III and IV of the right neck
Discussion
With increasing diagnostic experience, the class of “adenocarcinomas, not otherwise specified” in salivary glands is diminishing.2 In 1980, Batsakis3 was the first to use the term clear cell carcinoma of the salivary gland to describe what had previously been reported as a variant of ductal carcinoma or epithelial–myoepithelial carcinoma.4, 5 In 1994, the group was defined even further when a unique tumour with distinctive morphological features was identified by Milchgrub et al. and called a
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