ReviewAging and induced senescence as factors in the pathogenesis of lung emphysema
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Keywords
p53
HDAC
HAT
Methylation
Acetylation
SIRT1
Abbreviations
α1-AT
alpha-1-antitrypsin
Akt
serine-threonine-kinase, member of the protein kinase B (PKB) family
ALT
alternative mechanisms of telomere lengthening
Bad
Bcl-2-associated death promoter, member of the B-cell leukemia/lymphoma 2 (Bcl-2) family
Bax
member of the Bcl-2 family
CDK
cyclin-dependent kinase
COPD
chronic obstructive pulmonary disease
DHEAS
dehydroepiadrosterone sulphate
DNA
deoxyribonucleic acid
FOXO
forkhead box O
GM-CSF
granulocyte/macrophage-colony-stimulating factor
H2O2
hydrogen peroxide
HAT
histone acetyltransferase
HDAC
histone deacetylase
IL
interleukin
IGF-1
insulin-like growth factor 1
MMP
matrix metalloproteinase
PCNA
proliferating cell nuclear antigen
PI3K
phosphatidylinositol 3-kinase
pRb
retinoblastoma protein
PPAR-γ
peroxisome proliferator-activated receptor gamma
PTEN
phosphatase and tensin homolog, tyrosine and lipid phosphatase
RNA
ribonucleic acid
ROS
reactive oxygen species
SA-β-gal
senescence-associated β-galactosidase
SIPS
stress-induced proliferative senescence
Sir2
silent information regulator 2
SIRT1
homolog of Sir2 in mammals
TNF-α
tumor necrosis factor alpha
mTOR
mammalian target-of-rapamycin kinase
UV
ultraviolet
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