Elsevier

Schizophrenia Research

Volume 77, Issues 2–3, 15 September 2005, Pages 355-356
Schizophrenia Research

Letter to the Editors
Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia

https://doi.org/10.1016/j.schres.2005.03.012Get rights and content

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Acknowledgment

This work was funded by the Capital Medical Development Foundation (2002-3095), the National “211 Project” Peking University EBM Group (95000-246156082), and the Beijing Scientific and Technological New Stars Fund.

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    The BDNF val66met polymorphism has thus also been investigated for its association with declarative memory performance. While several studies have not shown an association between BDNF polymorphism and declarative memory measures (Benjamin et al., 2010; Gong et al., 2009; Houlihan et al., 2009; Karnik et al., 2010; Strauss et al., 2004; Tsai et al., 2008), several studies found that in samples of young adults, the BDNF met carriers had poorer verbal memory for items than the BDNF val homozygotes (Dempster et al., 2005; Egan et al., 2003; Hariri et al., 2003; Ho et al., 2006; Tan et al., 2005). Recent meta-analyses indicate that most of these studies relied mainly on tasks of item memory, and almost exclusively tested verbal memory (Kambeitz et al., 2012; Mandelmann and Grigorenko, 2012).

  • A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review

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    Important for the development of novel therapeutics and improved case management in primary care settings, it has also been shown that other BDNF gene variants and the Val66Met polymorphism are not only in linkage disequilibrium with one another but may also share an epistatic relationship by modulating neuroleptic responsiveness (Xu et al., 2010; Zai et al., 2012). Cognitive endophenotypes of schizophrenia, such as impaired prefrontal cognition and hippocampal-dependent memory deficits, have also been associated with Val66Met genotype amongst schizophrenia patients (Rybakowski et al., 2006; Tan et al., 2005). These genotype-linked cognitive deficits are supported by neuroimaging studies that have found that brain morphology is altered in schizophrenic carriers of the Val66Met polymorphism, and that this altered disorder-state morphology is similar albeit separate to that seen in healthy 66Met allele carriers (Agartz et al., 2006).

  • Soft-diet feeding after weaning affects behavior in mice: Potential increase in vulnerability to mental disorders

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    Furthermore, BDNF, a member of the neurotrophin family, is related to the survival and maintenance of neurons and the plasticity of neural circuits (Segal and Greenberg, 1996; Huang and Reichardt, 2003). Decreased BDNF expression in the hippocampus and decreased hippocampal volume have been reported in schizophrenic patients (Durany et al., 2001; Szeszko et al., 2005; Tan et al., 2005). Okayasu et al. (2004) investigated the relationship between BDNF expression and mastication by evaluating mandibular movement and mastication muscle activity in BDNF-deficient mice.

  • Effect of BDNF val<sup>66</sup>met polymorphism on declarative memory and its neural substrate: A meta-analysis

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    One hundred and six studies were excluded as either no episodic memory performance was reported, no BDNF-genotypes were reported, patients with a neurological disorder were investigated, no original data was reported (review article or meta-analysis), no human population was investigated (animal study) or there was an overlap in the investigated sample with other studies already included in the meta-analysis (see Fig. 1). Therefore 28 studies published between 2003 and 2011 matched the search criteria ((Hariri et al., 2003; Egan et al., 2003; Strauss et al., 2004; Tan et al., 2005; Dempster et al., 2005b; Harris et al., 2006; Ho et al., 2006; Hashimoto et al., 2008; Miyajima et al., 2008; Raz et al., 2008; Li et al., 2009; Matsuo et al., 2009; Schofield et al., 2009; Gong et al., 2009; Baig et al., 2010; Benjamin et al., 2010; Karnik et al., 2010; Cathomas et al., 2010; Richter-Schmidinger et al., 2011; Sambataro et al., 2010; van Wingen et al., 2010; Cerasa et al., 2010; Chung et al., 2010; Dennis et al., 2011; Kanellopoulos et al., 2011; Laing et al., 2011; Voineskos et al., 2011; Gruber et al., 2012), see Table 1). From the remaining studies, data were extracted from 32 independent samples resulting in a final sample of 5922 subjects.

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