AdherenceMedication Adherence of Patients with Selected Rheumatic Conditions: A Systematic Review of the Literature
Section snippets
Identification and Selection of Articles
A MEDLINE search of English language literature was performed to identify studies published between January 1, 1985 and November 30, 2007 that evaluated adherence, compliance, or persistence of medications for the treatment of rheumatic conditions. The following key words were used as search terms: (patient compliance or adherence or persistence or discontinuation or switching) and (ankylosing spondylitis, or arthritis, or gout, or psoriatic arthritis, or polymyalgia rheumatica, or rheumatoid
Characteristics of the Studies
The majority of studies focused on the treatment of rheumatoid arthritis (Table 1). There were 4 or fewer studies examining adherence in conditions including juvenile idiopathic arthritis (14, 24), polymyalgia rheumatica (25), systemic lupus erythematosus (26, 27, 28, 29), and gout (7, 25, 30). The most common medications studied were nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic agents (DMARDs). These studies employed a variety of study designs to assess
Discussion
This systematic review of the literature is the first to examine the current state of knowledge regarding the use of medications for the treatment of selected chronic inflammatory rheumatic conditions. Overall there were 20 studies that fulfilled criteria to be included in the review, the majority of which were focused on the treatment of rheumatoid arthritis. Many of the studies focused on treatments that are not commonly used today, including D-penicillamine and chronic high-dose salicylates.
References (44)
Prescription medication compliance: a review of the baseline of knowledge. A report of the national council on patient information and patient education
J Pharmacoepidemiol Drug Saf
(1995)Compliance with therapeutic regimens
(1976)Compliance and persistence with newer antihypertensive agents
Curr Hypertens Rep
(2002)- et al.
Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in community practice
J Rheumatol
(1993) - et al.
Adherence to medication
N Engl J Med
(2005) - et al.
A critical review of compliance studies in rheumatoid arthritis
Arthritis Rheum
(1984) - et al.
Compliance with allopurinol therapy among managed care enrollees with gout: a retrospective analysis of administrative claims
J Rheumatol
(2004) - et al.
Racial differences in analgesic/anti-inflammatory medication adherence among patients with osteoarthritis
Ethn Dis
(2005) Adherence with treatment regimens among adult rheumatoid arthritis patients: current status and future directions
Arthritis Care Res
(1989)- et al.
Compliance in rheumatoid arthritis and the role of formal patient education
Semin Arthritis Rheum
(1997)
Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research
Med Care
Compliance measurement with arthritis regimen
Arthritis Care Res
The effect of patient-practitioner interaction on compliance: a review of the literature and application in rheumatoid arthritis
Patient Educ Couns
Compliance with treatment regimens for pediatric rheumatic diseases
Arthritis Care Res
Management of adherence and chronic rheumatic disease in children and adolescents
Best Pract Res Clin Rheumatol
Caring for the adolescent with systemic lupus erythematosus
Adolesc Med
The epidemiology of drug treatment failure in rheumatoid arthritis
Baillieres Clin Rheumatol
Compliance revisited
Br J Rheumatol
Treatment adherence and clinical outcome in systemic lupus erythematosus
Rheumatology
Compliance and quality of life: confessions of a difficult patient
Arthritis Care Res
In rheumatoid arthritis is compliance in physicians more of a problem than compliance in patients?
Clin Rheumatol
‘Compliance' is futile but is ‘concordance' between rheumatology patients and health professionals attainable?
Rheumatology (Oxford)
Cited by (105)
Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review
2018, Seminars in Arthritis and RheumatismPipeline Therapies for Gout
2024, Current Rheumatology ReportsAdherence to biological therapies in patients with rheumatoid arthritis: a retrospective cohort study
2023, Rheumatology InternationalOptimizing adherence to allopurinol for gout: patients' perspectives
2023, British Journal of Clinical Pharmacology
Drs. Harrold and Andrade are investigators in the HMO Research Network Center for Education and Research on Therapeutics (Agency for Healthcare Research and Quality HS10391). Dr. Harrold was supported by Grant Number K23AR053856 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Arthritis and Musculoskeletal and Skin Diseases or the National Institutes of Health.