ReviewHuman RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology
Section snippets
Prologue
Homer's Odyssey is a beguiling work, a bookend—literally—to Western literature together with the Illiad. The Odyssey is a literal and metaphorical travelogue, the forced decadal wanderings of Odysseus following the end of the Trojan war. Voyaging, wandering and sailing are recurrent themes in the Odyssey, and have served ever since as powerful metaphors for life's journey and all attempts to explore and to wrest meaning from the unknown. The muse in the following story is Nature; our goal is
Conflicts of Interest
R.J.M., Jr. has no relevant conflicts of interest to declare.
Acknowledgements
Work in the author's laboratory has been supported by grants from the NIA, NCI and the Nippon Boehringer Ingelheim Virtual Research Institute of Aging. The author is grateful to lab members who have contributed many ideas and the hard work that made this review possible. This article is dedicated to three pioneers I have had the good fortune to know as mentors and colleagues: George Martin and Arno Motulsky, who first brought Werner syndrome to my—and many others’—attention; and Larry Loeb, a
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A Structural Guide to the Bloom Syndrome Complex
2021, StructureHuman RECQL5 promotes metastasis and resistance to cisplatin in non-small cell lung cancer
2021, Life SciencesCitation Excerpt :These results indicated that decreased expression of RECQL5 could enhance DDP sensitivity in NSCLC. RECQL5 is the last member of the RECQ helicase family, and it exerts regulatory roles in maintain genome stability and homologous recombination of genome, indicating RECQL5 may play the similar role in tumorigenesis or cancer susceptibility like other members of RECQ helicase family [23]. In the present study, by analyzing the publicly available database TCGA, we found that RECQL5 was upregulated in NSCLC tissues and the high abundance of RECQL5 could predict poor survival rate of LUAD patients, indicating the potential involvement of RECQL5 in NSCLC prognosis (Fig. 1A and B).
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
2020, Biochimica et Biophysica Acta - Reviews on CancerMining the role of RECQL5 in gastric cancer and seeking potential regulatory network by bioinformatics analysis
2020, Experimental and Molecular PathologySomatic mutations – Evolution within the individual
2020, MethodsCitation Excerpt :Notably, the telomere damage in the nucleus can trigger the activation of p53 that is associated with mitochondrial dysfunction, causing apoptosis and age-related dysfunction of the mitochondrion-rich quiescent tissues [27,28]. The most striking example that supports the somatic mutation theory is seen in patients suffering from inherited DNA repair deficits, who exhibit premature ageing-like phenotypes called Werner syndrome (WS or WRN) [29,30]. They have mutations through which the WRN gene product is lost, resulting in early onset cataracts, scleroderma, thinning grey hair, atherosclerosis, diabetes, myocardial infarction, stroke, osteoporosis, and cancers [29,31].