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The molecular machinery of autophagy and its role in physiology and disease

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  • Melanin, DNA replication, and autophagy affect appressorium development in Setosphaeria turcica by regulating glycerol accumulation and metabolism

    2022, Journal of Integrative Agriculture
    Citation Excerpt :

    Autophagy is a ubiquitous and evolutionarily conserved process in which long-lived proteins and organelles are degraded in all eukaryotic cells (Levine and Klionsky 2004). Beginning with the identification of autophagy-related (ATG) genes in yeast, studies of homologues in higher eukaryotes have reported that autophagy involves many aspects of physiology (Klionsky 2010). Autophagy is an important pathway of turgor accumulation in the appressorium (Veneault-Fourrey et al. 2006; Liu et al. 2007).

  • Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration

    2017, Developmental Cell
    Citation Excerpt :

    Autophagy is primarily a catabolic response to nutrient and energy deprivation, and is conserved from yeast to mammals (Klionsky, 2010).

  • An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: A proteomics approach

    2014, Free Radical Biology and Medicine
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    In addition to the above, an intriguing result of our study is suggested by the protein TER ATPase, also called valosin-containing protein (VCP), essential for autophagic processes [58]. Autophagy is a major degradative pathway for organelles and proteins [59]. Neurons are particularly dependent on autophagy for their survival [60,61].

  • Mitophagy and Parkinson's disease: Be eaten to stay healthy

    2013, Molecular and Cellular Neuroscience
    Citation Excerpt :

    During macroautophagy, a double-membrane cup-shaped structure engulfs cytosolic content forming an autophagic vesicle (AV). This AV then fuses with lysosomes, allowing hydrolytic enzymes in what are now autophagolysosomes to degrade the contents to their biochemical components (Klionsky, 2010). Autophagy is activated under conditions of both extracellular stress such as nutrient starvation, hypoxia, overcrowding and high temperatures, and intracellular stress.

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