Cell Stem Cell
Volume 8, Issue 1, 7 January 2011, Pages 84-95
ArticleEGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila
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Graphical Abstract
Highlights
► EGFR/MAPK signaling controls homeostasis and regeneration in the Drosophila midgut ► Within the niche, different cell types secrete EGFR ligands in response to stress ► EGFR activity is required and sufficient to promote intestinal stem cell division ► EGFR and Jak/Stat signaling act in synergy to induce ISC proliferation
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Present address: Department of Developmental Biology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390, USA
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