Cell Stem Cell
Volume 11, Issue 6, 7 December 2012, Pages 732-734
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Utf1: Goldilocks for ESC Bivalency

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Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.

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