Structure
Volume 18, Issue 10, 13 October 2010, Pages 1321-1331
ArticleFolding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI
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Highlights
► The GIY-YIG endonuclease family now has a representative structure bound to DNA ► The structure demonstrates how the GIY-YIG motif can recognize a specific DNA target ► Recognition of the DNA target by R.Eco29kI follows an unusual minimalistic strategy ► Minimal elaboration of the core fold permits site-specific target recognition
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