Structure
Volume 20, Issue 4, 4 April 2012, Pages 654-666
ArticleAsymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling
Under a Creative Commons license
open access
Graphical Abstract
Highlights
► S100A4 dimer binds single-myosin IIA molecule in an asymmetrical mode ► Synergy between Ca-dependent sites in S100A4 leads to high-affinity interaction ► Electron microscopy shows that two S100A4 dimers bind to the myosin coiled coil ► S100A4 has direct effect on formation of stress fibers and cell migration
Cited by (0)
- 8
These authors contributed equally to this work
- 9
Present address: Department of Chemistry & Biochemistry, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
Copyright © 2012 Elsevier Ltd.