ReviewAdvances in metal-induced oxidative stress and human disease
Abbreviations
NF-κB
nuclear factor kappa B
ATF
activating transcription factor
AP-1
activating protein
NFAT
nuclear factor of activated T-cells
IRPs
iron regulatory proteins
c-acon
aconitase
SOD
superoxide dismutase
HO-1
heme oxygenase
LIP
labile iron pool
8-OH-G
8-hydroxyguanine
ROO
peroxyl radicals
MDA
malondialdehyde
HNE
4-hydroxy-2-nonenal
NGAL
neutrophil gelatinase-associated lipocalin
HIF
hypoxia-inducible factor
VEGF
vascular endothelial growth factor
APP
amyloid precursor protein
NFT
neurofibrillary tangle
hCtr1
human copper transporter protein
HDL
high-density lipoprotein
LDL
low-density lipoprotein
TBARS
thiobarbituric acid-reactive substances
ONOO−
peroxynitrite anion
STAT3
signal transducer and activator of transcription 3
IFN
interferon
IL
interleukin
MNC
mononuclear cells
TNF-alpha
tumour necrosis factor
VCAM-1
vascular cell adhesion molecule-1
ROS
reactive oxygen species
RNS
reactive nitrogen species
VEGF
vascular endothelial growth factor
GR
glutathione reductase
ALA
delta-aminolevulinic acid
DMSA
meso-2,3-dimercaptosuccinic acid
ALAD
deltaaminolevulinic acid dehydrogenase
DFB
deferoxamine
CQ
5-chloro-7-iodoquinolin-8-ol
BAL
dimercaprol
Keywords
Metals
Fenton chemistry
Toxicity
Free radicals
Antioxidants
Redox cycling
Oxidative stress
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