Original article
Physiological role of the putative ammonium transporter RhCG in the mouseRôle physiologique du transporteur présumé de l'ammonium Rhcg chez la souris

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Abstract

Ammonium excretion into urine is a major process essential to the regulation of acid–base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene.

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