Elsevier

Virology

Volume 374, Issue 1, 25 April 2008, Pages 210-216
Virology

Human T-cell leukemia virus type 1 blunts signaling by interferon alpha

https://doi.org/10.1016/j.virol.2007.12.036Get rights and content
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Abstract

Although many animal viruses block the interferon (IFN) signaling pathway, this issue has not been previously investigated in retrovirus-infected cells. For this purpose, an infectious molecular clone of human T-cell leukemia virus type 1 (HTLV-1) was transfected into 293T or HeLa cells and was found to reduce interferon-stimulated response element (ISRE) reporter activity. This effect was independent of expression of the polymerase or envelope products and independent of the ability of Tax to activate the NFκB transcriptional pathway. IFN-α activation of 6 of 7 endogenous ISRE-regulated genes was also variably reduced, but not IFN-γ-activated response element-mediated expression of interferon regulatory factor 1. HTLV-1 reduced the phosphorylation of tyrosine kinase 2 (TYK2) and signal transducer and transcriptional activator 2 (STAT2), suggesting a specific effect of HTLV-1 on the ability of an adaptor tyrosine kinase to transfer an IFN signal to the STAT–transcriptional activator complex.

Keywords

HTLV
Type I interferon
STAT2
TYK2
Gag

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