Elsevier

Virology

Volume 411, Issue 2, 15 March 2011, Pages 153-162
Virology

Review
Innate immune sensing of DNA viruses

https://doi.org/10.1016/j.virol.2011.02.003Get rights and content
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Abstract

DNA viruses are a significant contributor to human morbidity and mortality. The immune system protects against viral infections through coordinated innate and adaptive immune responses. While the antigen-specific adaptive mechanisms have been extensively studied, the critical contributions of innate immunity to anti-viral defenses have only been revealed in the very recent past. Central to these anti-viral defenses is the recognition of viral pathogens by a diverse set of germ-line encoded receptors that survey nearly all cellular compartments for the presence of pathogens. In this review, we discuss the recent advances in the innate immune sensing of DNA viruses and focus on the recognition mechanisms involved.

Keywords

Innate immunity
Toll like receptors
Virus
Interferon
Inflammasome

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